We will begin in Florence for three days and then we have 7 days to explore Tuscany before heading to Rome for 4 days. I have looked at your itinerary suggestions for 7 days and was wondering what would be a good base so we are not having to pick up and move accommodation more than twice. We want to experience good wine and food and enjoy what this region has to offer. It is a our 25 wedding anniversary trip. All suggestions welcome. We will rent a car but would also like to enjoy wine tastings so will need to hire a car for those days. Is it best to rent the car from the Florence airport?